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PRP Joint Injections: Preparation and Recovery

Last updated: October 12, 2026 · Reviewed against current source guidance listed below

Before the appointment

A typical visit starts with a small blood draw, similar to routine labwork. Patients are often advised to avoid anti-inflammatory medications (like ibuprofen) for a period beforehand, since these can interfere with platelet function — always confirm this instruction with your own provider rather than assuming it applies to you.

What the injection itself involves

The drawn blood is processed in a centrifuge to concentrate the platelets, then injected into the target joint or tissue, usually in the same visit.

Aftercare and recovery

Mild soreness and swelling at the injection site for a day or two is common. Clinics generally recommend limiting strenuous use of the treated joint for a short period and following up to assess response, since PRP effects, when present, tend to build over weeks rather than appear immediately.

A typical PRP joint-injection visit, step by step
StageWhat typically happens
BeforeSmall blood draw; anti-inflammatory medications often paused beforehand
DuringBlood processed in a centrifuge, then injected into the target joint
AfterMild soreness/swelling for a day or two; limit strenuous use briefly
Follow-upResponse assessed over weeks, since effects build gradually
Key takeaways
  • The procedure starts with a routine-style blood draw, then a same-visit injection.
  • Anti-inflammatory medications may be paused beforehand on your provider's advice.
  • Benefits, if any, tend to develop over weeks rather than immediately.
When to see a doctor
  • Increasing pain, redness, warmth, or fever after the injection (possible infection).
  • No improvement at all after the timeframe your provider indicated.
This article is for general educational purposes only and is not medical advice. It does not replace diagnosis, treatment, or personalized recommendations from a licensed healthcare professional. Hands On Health is an independent blog and is not affiliated with any clinic.